Research theme: Modelling of biological systems

Keywords:systems biology, biotechnology, mathematical modelling, cell signalling, metabolism

A Systems Biologist experienced in qualitative and quantitative model construction, experimentation and data analysis. Biological robustness is harmonised by interconnected regulatory networks. I am interested in understanding how such regulation goes wrong, understanding how we can put it back right, and understanding the emerging phenotypes of such dysregulation using various quantitative and qualitative bioinformatic approaches including Flux Balance Analysis to model metabolism and boolean logical modelling to model cell signalling.

Publications

  • Gerassimidou, S., Martin, O. V., Chapman, S. P., Hahladakis, J. N., & Iacovidou, E. (2020). Development of an integrated sustainability matrix to depict challenges and trade-offs of introducing bio-based plastics in the food packaging value chain. Journal of Cleaner Production, 125378.

  • Stiles, W. A., Styles, D., Chapman, S. P., Esteves, S., Bywater, A., Melville, L., ... & Llewellyn, C. A. (2018). Using microalgae in the circular economy to valorise anaerobic digestate: challenges and opportunities. Bioresource technology, 267, 732-742.

  • Chapman, S. P. (2018). Use of membrane filtration technology to reduce agricultural pollution.

  • Chapman, S. P., Dos Santos, M. T., Johnson, G. N., Kritz, M. V., & Schwartz, J. M. (2017). Cyclic decomposition explains a photosynthetic down regulation for Chlamydomonas reinhardtii. Biosystems, 162, 119-127.

  • Chapman, S. P. (2016). A systems biology analysis of acetate metabolism and photosynthesis in Chlamydomonas reinhardtii. The University of Manchester (United Kingdom).

  • Chapman, S. P., Paget, C. M., Johnson, G. N., & Schwartz, J. M. (2015). Flux balance analysis reveals acetate metabolism modulates cyclic electron flow and alternative glycolytic pathways in Chlamydomonas reinhardtii. Frontiers in plant science, 6, 474